Biology:Mannose-1-phosphate guanylyltransferase (GDP)
From HandWiki
| mannose-1-phosphate guanylyltransferase (GDP) | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.7.22 | ||||||||
| CAS number | 9026-31-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) is an enzyme that catalyzes the chemical reaction
- GDP + alpha-D-mannose 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] phosphate + GDP-mannose
Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are phosphate and GDP-mannose.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GDP:alpha-D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.
Other common names
- GDP mannose phosphorylase
- Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase
- GDP mannose phosphorylase
- GDP-mannose 1-phosphate guanylyltransferase
- Guanosine diphosphate-mannose 1-phosphate guanylyltransferase
- Guanosine diphosphomannose phosphorylase
- Mannose 1-phosphate guanylyltransferase
- GDP:D-mannose-1-phosphate guanylyltransferase
References
- "Phosphorolysis of the pyrophosphate bond of some nucleotides". Biochim. Biophys. Acta 53 (2): 417–9. 1961. doi:10.1016/0006-3002(61)90458-9. PMID 13876695.
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