Biology:Acetoacetyl-CoA hydrolase
From HandWiki
Short description: Class of enzymes
| acetoacetyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.11 | ||||||||
| CAS number | 37288-10-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme acetoacetyl-CoA hydrolase (EC 3.1.2.11) catalyzes the reaction
- acetoacetyl-CoA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] CoA + acetoacetate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase. This enzyme participates in butanoate metabolism.
References
- "A survey of enzymes which generate or use acetoacetyl thioesters in rat liver". J. Biol. Chem. 258 (8): 4725–33. 1983. PMID 6131897.
- "Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver". J. Biol. Chem. 235: 318–25. 1960. PMID 13818236.
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