Biology:CXCL13
 Generic protein structure example |
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.[1][2]
Function
CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.[1][3] CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues[4] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans.[1] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.[2]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[5]
References
- ↑ 1.0 1.1 1.2 "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. February 1998. doi:10.1084/jem.187.4.655. PMID 9463416.
- ↑ 2.0 2.1 "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature 391 (6669): 799–803. February 1998. doi:10.1038/35876. PMID 9486651. Bibcode: 1998Natur.391..799G.
- ↑ "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity 16 (1): 67–76. January 2002. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.
- ↑ "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature 406 (6793): 309–14. July 2000. doi:10.1038/35018581. PMID 10917533.
- ↑ "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood 109 (11): 4952–63. June 2007. doi:10.1182/blood-2006-10-055145. PMID 17284527.
External links
- Human CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: O43927 (C-X-C motif chemokine 13) at the PDBe-KB.
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