Biology:CCL16
| chemokine (C-C motif) ligand 16 | |
|---|---|
| Identifiers | |
| Symbol | CCL16 |
| Alt. symbols | SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1 |
| NCBI gene | 6360 |
| HGNC | 10614 |
| OMIM | 601394 |
| RefSeq | NM_004590 |
| UniProt | O15467 |
| Other data | |
| Locus | Chr. 17 q11.2 |
Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes.[1] Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines.[2] CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8.[3][4]
C-C motif chemokine ligand 16 has been found in high levels in the blood plasma of humans.[5] CCL16 may be useful for trafficking eosinophils. This ligand has been found to have a functional affinity for H4 receptors that are expressed by eosinophils and mast cells.[5] This chemokine has been shown to suppress rapid proliferation of myeloid progenitor cells.[6]
References
- ↑ "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity". Biochemical and Biophysical Research Communications 247 (2): 217–22. June 1998. doi:10.1006/bbrc.1998.8762. PMID 9642106.
- ↑ "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES". Journal of Interferon & Cytokine Research 19 (3): 227–34. March 1999. doi:10.1089/107999099314153. PMID 10213461.
- ↑ "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes". International Immunology 13 (8): 1021–9. August 2001. doi:10.1093/intimm/13.8.1021. PMID 11470772.
- ↑ "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood 96 (3): 840–5. August 2000. doi:10.1182/blood.V96.3.840. PMID 10910894.
- ↑ 5.0 5.1 "Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor". Journal of Immunology 173 (3): 2078–83. August 2004. doi:10.4049/jimmunol.173.3.2078. PMID 15265943.
- ↑ "CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human) Gene"]. National Center for Biotechnology Information, U.S. National Library of Medicine. https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=6360.
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