Biology:CXCR6
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[1][2][3] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).
CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[1][2][3][4] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[4] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.
References
- ↑ 1.0 1.1 "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine 185 (11): 2015–23. June 1997. doi:10.1084/jem.185.11.2015. PMID 9166430.
- ↑ 2.0 2.1 "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature 388 (6639): 296–300. July 1997. doi:10.1038/40894. PMID 9230441. Bibcode: 1997Natur.388..296D.
- ↑ 3.0 3.1 "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10663.
- ↑ 4.0 4.1 "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology 89 (18): 9252–61. September 2015. doi:10.1128/JVI.01236-15. PMID 26109719.
Further reading
- "HIV-1 infection and chemokine receptor modulation". Current HIV Research 2 (1): 39–50. January 2004. doi:10.2174/1570162043484997. PMID 15053339.
- "TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function". Current Biology 7 (9): 652–60. September 1997. doi:10.1016/S0960-9822(06)00292-2. PMID 9285716.
- "HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors". Proceedings of the National Academy of Sciences of the United States of America 95 (19): 11360–5. September 1998. doi:10.1073/pnas.95.19.11360. PMID 9736741. Bibcode: 1998PNAS...9511360H.
- "Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease". Journal of Virology 74 (1): 184–92. January 2000. doi:10.1128/JVI.74.1.184-192.2000. PMID 10590105.
- "Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1". Journal of Acquired Immune Deficiency Syndromes 24 (1): 1–9. May 2000. doi:10.1097/00126334-200005010-00001. PMID 10877489.
- "The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells". AIDS Research and Human Retroviruses 16 (11): 1055–9. July 2000. doi:10.1089/08892220050075318. PMID 10933620.
- "The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse". Journal of Immunology 165 (6): 3284–92. September 2000. doi:10.4049/jimmunol.165.6.3284. PMID 10975845.
- "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo". Nature Immunology 1 (4): 298–304. October 2000. doi:10.1038/79738. PMID 11017100.
- "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines". Journal of Immunology 166 (8): 5145–54. April 2001. doi:10.4049/jimmunol.166.8.5145. PMID 11290797.
- "cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor". Journal of Virology 75 (24): 12028–38. December 2001. doi:10.1128/JVI.75.24.12028-12038.2001. PMID 11711593.
- "Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells". Journal of Neuroimmunology 127 (1–2): 96–105. June 2002. doi:10.1016/S0165-5728(02)00106-6. PMID 12044980.
- "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood 100 (1): 11–6. July 2002. doi:10.1182/blood-2001-12-0196. PMID 12070001.
- "Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans". Genes and Immunity 4 (4): 245–50. June 2003. doi:10.1038/sj.gene.6363950. PMID 12761559.
- "Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin". Cellular Immunology 223 (1): 1–12. May 2003. doi:10.1016/S0008-8749(03)00130-8. PMID 12914753.
- "Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells". Journal of Leukocyte Biology 75 (2): 267–74. February 2004. doi:10.1189/jlb.1003465. PMID 14634054.
External links
- "Chemokine Receptors: CXCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2873.
- Human CXCR6 genome location and CXCR6 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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