Biology:CXCL6
From HandWiki
Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
| chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | |
|---|---|
| Identifiers | |
| Symbol | CXCL6 |
| Alt. symbols | SCYB6, GCP-2, CKA-3 |
| NCBI gene | 6372 |
| HGNC | 10643 |
| OMIM | 138965 |
| RefSeq | NM_002993 |
| UniProt | P80162 |
| Other data | |
| Locus | Chr. 4 q21 |
Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.[1][2] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.[2] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.[3][4]
References
- ↑ "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry 32 (38): 10170–7. 1993. doi:10.1021/bi00089a037. PMID 8399143.
- ↑ 2.0 2.1 "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry 36 (9): 2716–23. 1997. doi:10.1021/bi961999z. PMID 9054580.
- ↑ "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics 47 (1): 136–9. 1998. doi:10.1006/geno.1997.5100. PMID 9465307. https://zenodo.org/record/1229776.
- ↑ "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet 84 (1–2): 39–42. 1999. doi:10.1159/000015209. PMID 10343098.
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