Biology:CCL19
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.[1][2]
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.[2]
Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.[3] The gene for CCL19 is located on human chromosome 9.[4] This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.[3] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,[5][6] CCR7+ central-memory T-Cells.[7]
References
- ↑ "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem 272 (21): 13803–9. Jul 1997. doi:10.1074/jbc.272.21.13803. PMID 9153236.
- ↑ 2.0 2.1 "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6363.
- ↑ 3.0 3.1 "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. 1997. doi:10.1074/jbc.272.21.13803. PMID 9153236.
- ↑ "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. 1997. doi:10.4049/jimmunol.158.3.1033. PMID 9013939. http://www.jimmunol.org/cgi/content/abstract/158/3/1033.
- ↑ "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell 103 (5): 757–68. 2000. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332.
- ↑ "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature 416 (6876): 94–9. 2002. doi:10.1038/416094a. PMID 11882900. Bibcode: 2002Natur.416...94R.
- ↑ "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. 2005. doi:10.1038/ni1240. PMID 16116469.
Further reading
- "Fine-tuning leukocyte responses: towards a chemokine 'interactome'.". Trends Immunol. 27 (6): 268–73. 2006. doi:10.1016/j.it.2006.04.002. PMID 16678487.
- Rossi DL; Vicari AP; Franz-Bacon K et al. (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. doi:10.4049/jimmunol.158.3.1033. PMID 9013939.
- Nagira M; Imai T; Hieshima K et al. (1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". J. Biol. Chem. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.
- Kim CH; Pelus LM; White JR et al. (1998). "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells". J. Immunol. 160 (5): 2418–24. doi:10.4049/jimmunol.160.5.2418. PMID 9498785.
- Yanagihara S; Komura E; Nagafune J et al. (1998). "EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation". J. Immunol. 161 (6): 3096–102. doi:10.4049/jimmunol.161.6.3096. PMID 9743376.
- Gosling J; Dairaghi DJ; Wang Y et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
- Annunziato F; Romagnani P; Cosmi L et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection". J. Immunol. 165 (1): 238–46. doi:10.4049/jimmunol.165.1.238. PMID 10861057.
- Ueno T; Hara K; Willis MS et al. (2002). "Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus". Immunity 16 (2): 205–18. doi:10.1016/S1074-7613(02)00267-4. PMID 11869682.
- "Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells". Eur. J. Immunol. 32 (3): 837–47. 2002. doi:10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q. PMID 11870628.
- "The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes". Blood 99 (8): 2977–84. 2002. doi:10.1182/blood.V99.8.2977. PMID 11929789.
- "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR". Eur. J. Immunol. 32 (5): 1230–41. 2002. doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. PMID 11981810.
- "Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium". J. Immunol. 168 (10): 5333–41. 2002. doi:10.4049/jimmunol.168.10.5333. PMID 11994492.
- Katou F; Ohtani H; Nakayama T et al. (2003). "Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin". J. Pathol. 199 (1): 98–106. doi:10.1002/path.1255. PMID 12474232.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Scandella E; Men Y; Legler DF et al. (2004). "CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2". Blood 103 (5): 1595–601. doi:10.1182/blood-2003-05-1643. PMID 14592837.
- Corcione A; Arduino N; Ferretti E et al. (2004). "CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells". Clin. Cancer Res. 10 (3): 964–71. doi:10.1158/1078-0432.CCR-1182-3. PMID 14871974.
- Daikoku N; Kitaya K; Nakayama T et al. (2004). "Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle". Fertil. Steril. 81 (Suppl 1): 876–81. doi:10.1016/j.fertnstert.2003.09.036. PMID 15019823.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Paoletti S; Petkovic V; Sebastiani S et al. (2005). "A rich chemokine environment strongly enhances leukocyte migration and activities". Blood 105 (9): 3405–12. doi:10.1182/blood-2004-04-1648. PMID 15546958.
External links
- Human CCL19 genome location and CCL19 gene details page in the UCSC Genome Browser.
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