Biology:CCL3
 Generic protein structure example |
Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[1]
Function
CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[2] through binding to the receptors CCR1, CCR4 and CCR5.[1]
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[3][1]
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[4]
Interactions
CCL3 has been shown to interact with CCL4.[5] Attracts macrophages, monocytes and neutrophils.
See also
References
- ↑ 1.0 1.1 1.2 "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6348.
- ↑ "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine 167 (2): 570–81. 1988. doi:10.1084/jem.167.2.570. PMID 3279154.
- ↑ "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine 168 (6): 2251–9. 1988. doi:10.1084/jem.168.6.2251. PMID 3058856.
- ↑ "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science 243 (4894 Pt 1): 1066–8. 1989. doi:10.1126/science.2646711. PMID 2646711. Bibcode: 1989Sci...243.1066D.
- ↑ "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry 276 (15): 12404–9. Apr 2001. doi:10.1074/jbc.M006327200. PMID 11278300.
External links
- Human CCL3 genome location and CCL3 gene details page in the UCSC Genome Browser.
Further reading
- "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews 13 (6): 455–81. Dec 2002. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
- "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology 23 (4): 239–47. Apr 2004. doi:10.1089/104454904773819824. PMID 15142381.
- "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research 3 (1): 87–94. Jan 2005. doi:10.2174/1570162052773013. PMID 15638726.
- "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. Mar 2005. doi:10.1038/sj.cr.7290279. PMID 15780175.
- "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. Apr 2005. PMID 15817944.
- "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research 15 (11–12): 923–34. 2006. doi:10.1038/sj.cr.7290370. PMID 16354571.
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