Biology:CCR1
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Short description: Protein in humans
 Generic protein structure example |
C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.[1]
CCR1 has also recently been designated CD191 (cluster of differentiation 191).
Function
This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.[2]
Interactions
CCR1 has been shown to interact with CCL5.[3][4]
References
- ↑ "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell 72 (3): 415–25. February 1993. doi:10.1016/0092-8674(93)90118-A. PMID 7679328.
- ↑ "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1230.
- ↑ "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". European Journal of Immunology 31 (7): 2170–8. July 2001. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.
- ↑ "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry 276 (14): 10620–6. April 2001. doi:10.1074/jbc.M010867200. PMID 11116158.
Further reading
- "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology 12 (1): 775–808. 1994. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
- "HIV-1 infection and chemokine receptor modulation". Current HIV Research 2 (1): 39–50. January 2004. doi:10.2174/1570162043484997. PMID 15053339.
- "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology 5 (10): 1239–49. October 1993. doi:10.1093/intimm/5.10.1239. PMID 7505609.
- "Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3". The Journal of Biological Chemistry 270 (38): 22123–8. September 1995. doi:10.1074/jbc.270.38.22123. PMID 7545673.
- "Molecular characterization of two murine eosinophil beta chemokine receptors". Journal of Immunology 155 (11): 5299–305. December 1995. doi:10.4049/jimmunol.155.11.5299. PMID 7594543.
- "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor". The Journal of Experimental Medicine 177 (5): 1421–7. May 1993. doi:10.1084/jem.177.5.1421. PMID 7683036.
- "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B". The Journal of Biological Chemistry 270 (50): 29671–5. December 1995. doi:10.1074/jbc.270.50.29671. PMID 8530354.
- "Selective G protein coupling by C-C chemokine receptors". The Journal of Biological Chemistry 271 (8): 3975–8. February 1996. doi:10.1074/jbc.271.8.3975. PMID 8626727.
- "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9". The Journal of Biological Chemistry 271 (13): 7551–8. March 1996. doi:10.1074/jbc.271.13.7551. PMID 8631787.
- "Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors". The Journal of Biological Chemistry 272 (18): 11682–5. May 1997. doi:10.1074/jbc.272.18.11682. PMID 9115216.
- "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics 41 (2): 294–5. April 1997. doi:10.1006/geno.1997.4626. PMID 9143512.
- "Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5". Biochemistry 36 (32): 9642–8. August 1997. doi:10.1021/bi970593z. PMID 9289016.
- "Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines". European Journal of Biochemistry 248 (2): 507–15. September 1997. doi:10.1111/j.1432-1033.1997.00507.x. PMID 9346309.
- "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1". Blood 91 (9): 3118–26. May 1998. doi:10.1182/blood.V91.9.3118. PMID 9558365.
- "Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1". Journal of Immunology 162 (1): 435–44. January 1999. doi:10.4049/jimmunol.162.1.435. PMID 9886417.
- "Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection". NeuroReport 10 (1): 53–6. January 1999. doi:10.1097/00001756-199901180-00010. PMID 10094132. https://zenodo.org/record/1234764.
- "Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1". Journal of Immunology 162 (8): 4938–42. April 1999. doi:10.4049/jimmunol.162.8.4938. PMID 10202040.
- "Use of chemokine receptors by poxviruses". Science 286 (5446): 1968–71. December 1999. doi:10.1126/science.286.5446.1968. PMID 10583963.
External links
- Human CCR1 genome location and CCR1 gene details page in the UCSC Genome Browser.
- "Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2220.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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