Biology:S-formylglutathione hydrolase
From HandWiki
| S-formylglutathione hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.12 | ||||||||
| CAS number | 50812-21-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme S-formylglutathione hydrolase (EC 3.1.2.12) catalyzes the reaction
- S-formylglutathione + H2O [math]\displaystyle{ \rightleftharpoons }[/math] glutathione + formate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is S-formylglutathione hydrolase. It participates in methane metabolism.
References
- Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases". Biochemistry 12 (20): 3938–43. doi:10.1021/bi00744a024. PMID 4200890.
- "Purification and properties of S-formylglutathione hydrolase from human liver". J. Biol. Chem. 249 (23): 7664–72. 1974. PMID 4436331.
- "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?". J. Bacteriol. 178 (21): 6296–9. 1996. PMID 8892832.
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