Biology:60S ribosomal protein L18a
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.[1][2]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18AE family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U68 snoRNA, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]
References
- ↑ "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. Aug 1998. doi:10.1101/gr.8.5.509. PMID 9582194.
- ↑ 2.0 2.1 "Entrez Gene: RPL18A ribosomal protein L18a". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6142.
Further reading
- "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. 1996. doi:10.1139/o95-101. PMID 8722009.
- "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. 1992. doi:10.1038/355632a0. PMID 1538749. Bibcode: 1992Natur.355..632A.
- "The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation?". Biol. Chem. Hoppe-Seyler 376 (5): 321–5. 1995. doi:10.1515/bchm3.1995.376.5.321. PMID 7662174.
- "Construction of a human full-length cDNA bank". Gene 150 (2): 243–50. 1995. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. 2002. doi:10.1093/emboj/21.3.377. PMID 11823430.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. 2005. doi:10.1038/nbt1046. PMID 15592455.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site". Arch. Virol. 151 (3): 509–24. 2006. doi:10.1007/s00705-005-0642-6. PMID 16195786.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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