Biology:40S ribosomal protein S16
 Generic protein structure example |
40S ribosomal protein S16' is a protein that in humans is encoded by the RPS16 gene.[1][2][3]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]
Interactions
Ribosomal protein S16 is one of the proteins from the small ribosomal subunit. It belongs to a ribosomal protein family that is divided into three groups based on sequence similarity:
* Eubacterial S16.
* Algal and plant chloroplast S16.
* Cyanelle S16.
* Neurospora crassa mitochondrial S24 (cyt-21).
S16 proteins have about 100 amino-acid residues. There are two paralogues in Arabidopsis thaliana, RPS16-1 (chloroplastic) and RPS16-2 (targeted to the chloroplast and the mitochondrion)
[4].
RPS16 has been shown to interact with CDC5L.[4]
References
- ↑ "Molecular cloning and sequence analysis of the human ribosomal protein S16". J Biol Chem 266 (11): 6830–3. May 1991. doi:10.1016/S0021-9258(20)89575-1. PMID 2016298.
- ↑ "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. August 1998. doi:10.1101/gr.8.5.509. PMID 9582194.
- ↑ 3.0 3.1 "Entrez Gene: RPS16 ribosomal protein S16". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6217.
- ↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMID 11101529.
Further reading
- "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. 1996. doi:10.1139/o95-101. PMID 8722009.
- "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. 1995. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
- "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. 1996. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein.". J. Cell Sci. 113 Pt 24 (24): 4523–31. 2001. doi:10.1242/jcs.113.24.4523. PMID 11082045.
- "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". EMBO J. 19 (23): 6569–81. 2001. doi:10.1093/emboj/19.23.6569. PMID 11101529.
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.". Genome Res. 12 (3): 379–90. 2002. doi:10.1101/gr.214202. PMID 11875025.
- "Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells.". Carcinogenesis 23 (6): 967–75. 2002. doi:10.1093/carcin/23.6.967. PMID 12082018.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. 2005. doi:10.1110/ps.041293005. PMID 15883184.
- "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell. Proteomics 6 (4): 575–88. 2007. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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