Biology:Ethanolamine-phosphate cytidylyltransferase
| ethanolamine-phosphate cytidylyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.7.14 | ||||||||
| CAS number | 9026-33-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) is an enzyme that catalyzes the chemical reaction
- CTP + ethanolamine phosphate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + CDP-ethanolamine
Thus, the two substrates of this enzyme are CTP and ethanolamine phosphate, whereas its two products are diphosphate and CDP-ethanolamine.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:ethanolamine-phosphate cytidylyltransferase. Other names in common use include phosphorylethanolamine transferase, ET, CTP-phosphoethanolamine cytidylyltransferase, phosphoethanolamine cytidylyltransferase, and ethanolamine phosphate cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.
References
- "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222 (1): 193–214. 1956. PMID 13366993.
- Sundler R (1975). "Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver". J. Biol. Chem. 250 (22): 8585–90. PMID 241749.
- "2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity". Biochem. J. 260 (1): 299–301. 1989. PMID 2549956.
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