Biology:N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
From HandWiki
Short description: Enzyme involved in biosynthesis of anandamide
| N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.54 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name 'N-acetylphosphatidylethanolamine phosphatidohydrolase.[1][2] It catalyses the following chemical reaction
- N-acylphosphatidylethanolamine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate
This enzyme is involved in the biosynthesis of anandamide.
See also
References
- ↑ "Molecular characterization of a phospholipase D generating anandamide and its congeners". The Journal of Biological Chemistry 279 (7): 5298–305. February 2004. doi:10.1074/jbc.M306642200. PMID 14634025.
- ↑ "Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family". The Journal of Biological Chemistry 281 (18): 12325–35. May 2006. doi:10.1074/jbc.M512359200. PMID 16527816.
- Magotti, Paola; Bauer, Inga; Igarashi, Miki; Babagoli, Masih; Marotta, Roberto; Piomelli, Daniele; Garau, Gianpiero (March 2015). "Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure 23 (3): 598–604. doi:10.1016/j.str.2014.12.018. PMID 25684574.
External links
- N-acetylphosphatidylethanolamine-hydrolysing+phospholipase+D at the US National Library of Medicine Medical Subject Headings (MeSH)
- N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD ((C7orf18, FMP30, NAPE-PLD)) Human Protein Atlas
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