Biology:Glycosylphosphatidylinositol phospholipase D
From HandWiki
| Glycosylphosphatidylinositol phospholipase D | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.4.50 | ||||||||
| CAS number | 113756-14-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myoinositol + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 6-(α-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.
See also
References
- ↑ "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma". Proceedings of the National Academy of Sciences of the United States of America 85 (4): 980–4. February 1988. doi:10.1073/pnas.85.4.980. PMID 3422494. Bibcode: 1988PNAS...85..980L.
- ↑ "Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases". The Biochemical Journal 240 (2): 519–27. December 1986. doi:10.1042/bj2400519. PMID 3028377.
- ↑ "Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies". The Journal of Biological Chemistry 269 (46): 28963–71. November 1994. doi:10.1016/S0021-9258(19)62000-4. PMID 7961859.
- ↑ "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". Journal of Lipid Research 42 (3): 442–51. March 2001. doi:10.1016/S0022-2275(20)31669-2. PMID 11254757.
External links
- Glycosylphosphatidylinositol+phospholipase+D at the US National Library of Medicine Medical Subject Headings (MeSH)
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