Biology:PLCD3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.[1][2][3]
Function
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca2+ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.[3]
References
- ↑ "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics 87 (3–4): 209–10. Apr 2000. doi:10.1159/000015469. PMID 10702670.
- ↑ "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expression and Purification 9 (2): 262–78. Mar 1997. doi:10.1006/prep.1996.0682. PMID 9056492.
- ↑ 3.0 3.1 "Entrez Gene: PLCD3 phospholipase C, delta 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026.
Further reading
- "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". The Journal of Clinical Investigation 86 (6): 2117–24. Dec 1990. doi:10.1172/JCI114950. PMID 1979339.
- "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". European Journal of Immunology 25 (9): 2695–700. Sep 1995. doi:10.1002/eji.1830250944. PMID 7589147.
- "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". The Journal of Biological Chemistry 272 (36): 22385–8. Sep 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3". Acta Biochimica Polonica 44 (2): 221–9. 1998. doi:10.18388/abp.1997_4417. PMID 9360711.
- "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. 1998. doi:10.1159/000026336. PMID 9730685.
- "Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium". European Journal of Biochemistry 257 (1): 169–77. Oct 1998. doi:10.1046/j.1432-1327.1998.2570169.x. PMID 9799116.
- "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes". European Journal of Biochemistry 262 (2): 291–8. Jun 1999. doi:10.1046/j.1432-1327.1999.00388.x. PMID 10336610.
- "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". Journal of Neurochemistry 73 (4): 1363–74. Oct 1999. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
- "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology 164 (12): 6538–42. Jun 2000. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
- "Downregulation of phospholipase C delta3 by cAMP and calcium". Biochemical and Biophysical Research Communications 286 (2): 274–80. Aug 2001. doi:10.1006/bbrc.2001.5371. PMID 11500033.
- "Membrane targeting of C2 domains of phospholipase C-delta isoforms". The Journal of Biological Chemistry 277 (5): 3568–75. Feb 2002. doi:10.1074/jbc.M109705200. PMID 11706040.
- "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research 8 (6): 319–27. Dec 2001. doi:10.1093/dnares/8.6.319. PMID 11853319.
- "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. Nov 2002. doi:10.1006/viro.2002.1676. PMID 12482669.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. Jul 2004. doi:10.1101/gr.2334104. PMID 15231748.
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