Biology:CDS1 (gene)
 Generic protein structure example |
Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.[1][2][3]
Function
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[4][5] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.[3]
References
- ↑ "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics 54 (1): 140–4. November 1998. doi:10.1006/geno.1998.5547. PMID 9806839.
- ↑ "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology 16 (3): 281–9. March 1997. doi:10.1089/dna.1997.16.281. PMID 9115637.
- ↑ 3.0 3.1 "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1040.
- ↑ "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters 579 (10): 2161–5. April 2005. doi:10.1016/j.febslet.2005.03.007. PMID 15811335.
- ↑ Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.
Further reading
- "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha". Cancer Research 62 (22): 6357–61. November 2002. PMID 12438214.
- "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics 55 (1): 68–77. January 1999. doi:10.1006/geno.1998.5610. PMID 9889000.
- "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". The Journal of Biological Chemistry 272 (52): 33402–9. December 1997. doi:10.1074/jbc.272.52.33402. PMID 9407135.
- "Cloning of CDP-diacylglycerol synthase from a human neuronal cell line". Journal of Neurochemistry 67 (5): 2200–3. November 1996. doi:10.1046/j.1471-4159.1996.67052200.x. PMID 8863531. https://deepblue.lib.umich.edu/bitstream/2027.42/65959/1/j.1471-4159.1996.67052200.x.pdf.
External links
- Human CDS1 genome location and CDS1 gene details page in the UCSC Genome Browser.
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