Biology:Amphinase
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Amphinase | |||||||
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![]() Crystallographic structure of amphinase.[1] | |||||||
Identifiers | |||||||
Organism | |||||||
Symbol | n/a | ||||||
PDB | 2P7S (ECOD) | ||||||
UniProt | P85073 | ||||||
Other data | |||||||
EC number | 3.1.27 | ||||||
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Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates.[2] Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells.[3]
References
- ↑ "Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes". Journal of Molecular Biology 371 (1): 93–111. August 2007. doi:10.1016/j.jmb.2007.04.071. PMID 17560606.
- ↑ "Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes". Journal of Molecular Biology 371 (1): 93–111. August 2007. doi:10.1016/j.jmb.2007.04.071. PMID 17560606.
- ↑ "Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes". Current Pharmaceutical Biotechnology 9 (3): 215–25. June 2008. doi:10.2174/138920108784567245. PMID 18673287.
![]() | Original source: https://en.wikipedia.org/wiki/Amphinase.
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