Biology:3-hydroxyisobutyryl-CoA hydrolase
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Short description: Class of enzymes
| 3-hydroxyisobutyryl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-hydroxyisobutyryl-CoA hydrolase monomer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 3.1.2.4 | ||||||||
| CAS number | 9025-88-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) catalyzes the reaction
- 3-hydroxy-2-methylpropanoyl-CoA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] CoA + 3-hydroxy-2-methylpropanoate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, β-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.[1]
References
- "Enzymatic hydrolysis of the coenzyme A thiol esters of β-hydroxypropionic and β-hydroxyisobutyric acids". The Journal of Biological Chemistry 225 (1): 523–34. March 1957. PMID 13457352.
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