Biology:60S ribosomal protein L27a
 Generic protein structure example |
60S ribosomal protein L27a is a protein that in humans is encoded by the RPL27A gene.[1][2][3]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome.[3]
References
- ↑ "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta 1262 (1): 64–8. Jul 1995. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
- ↑ "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. Aug 1998. doi:10.1101/gr.8.5.509. PMID 9582194.
- ↑ 3.0 3.1 "Entrez Gene: RPL27A ribosomal protein L27a". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6157.
Further reading
- "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–947. 1996. doi:10.1139/o95-101. PMID 8722009.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Andersen JS; Lyon CE; Fox AH et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics 17 (12): 1152–1157. 2002. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
- Kusuda J; Hirai M; Tanuma R et al. (1999). "Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A". Cytogenet. Cell Genet. 85 (3–4): 248–251. doi:10.1159/000015303. PMID 10449908.
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