Biology:60S ribosomal protein L35a
 Generic protein structure example |
60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.[1][2][3]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]
References
- ↑ "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics 13 (1): 201–7. Jun 1992. doi:10.1016/0888-7543(92)90221-D. PMID 1577483.
- ↑ "The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter". Genomics 32 (1): 148–50. Sep 1996. doi:10.1006/geno.1996.0093. PMID 8786106.
- ↑ 3.0 3.1 "Entrez Gene: RPL35A ribosomal protein L35a". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6165.
Further reading
- "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. 1996. doi:10.1139/o95-101. PMID 8722009.
- "cDNA encoding the human homologue of rat ribosomal protein L35a". Nucleic Acids Res. 18 (15): 4600. 1990. doi:10.1093/nar/18.15.4600. PMID 2388839.
- "Construction of a human full-length cDNA bank". Gene 150 (2): 243–50. 1995. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
- "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. 1998. doi:10.1101/gr.8.5.509. PMID 9582194.
- "The identification of novel therapeutic targets for the treatment of malignant brain tumors". Cancer Lett. 156 (2): 191–8. 2000. doi:10.1016/S0304-3835(00)00462-6. PMID 10880769.
- "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. 2002. doi:10.1101/gr.214202. PMID 11875025.
- "Inhibition of cell death by ribosomal protein L35a". Cancer Lett. 180 (2): 195–202. 2002. doi:10.1016/S0304-3835(02)00024-1. PMID 12175552.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74. 2003. doi:10.1177/002215540305100502. PMID 12704204.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
External links
 |
