Biology:ADK (gene)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.

Function

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg²⁺ for activity.

External links

• Human ADK genome location and ADK gene details page in the UCSC Genome Browser.

Further reading

• "Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel.". Cytogenet. Cell Genet. 16 (1–5): 171–4. 1976. doi:10.1159/000130582. PMID 185014. 
• "Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene". Eur. J. Biochem. 241 (2): 564–71. 1996. doi:10.1111/j.1432-1033.1995.tb20220.x_1. PMID 8917457. 
• "Cloning and expression of the adenosine kinase gene from rat and human tissues". Biochem. Biophys. Res. Commun. 231 (3): 645–50. 1997. doi:10.1006/bbrc.1997.6157. PMID 9070863. 
• "Structure of human adenosine kinase at 1.5 A resolution". Biochemistry 37 (45): 15607–20. 1998. doi:10.1021/bi9815445. PMID 9843365. 
• "Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein". Eur. J. Biochem. 261 (2): 509–17. 1999. doi:10.1046/j.1432-1327.1999.00294.x. PMID 10215863. 
• "Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons". DNA Cell Biol. 20 (1): 53–65. 2001. doi:10.1089/10445490150504693. PMID 11242543. 
• "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics 2 (6): 642–8. 2003. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. 2003. doi:10.1007/s00232-002-1073-x. PMID 12820662. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.