Biology:Acetylajmaline esterase
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Short description: Class of enzymes
| Acetylajmaline esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.80 | ||||||||
| CAS number | 110183-46-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme acetylajmaline esterase (EC 3.1.1.80, AAE, 2β(R)-17-O-acetylajmalan:acetylesterase, acetylajmalan esterase; systematic name 17-O-acetylajmaline O-acetylhydrolase)[1][2] catalyses the following reactions:
- (1) 17-O-acetylajmaline + H2O [math]\displaystyle{ \rightleftharpoons }[/math] ajmaline + acetate
- (2) 17-O-acetylnorajmaline + H2O [math]\displaystyle{ \rightleftharpoons }[/math] norajmaline + acetate
This plant enzyme mediates the last stages in the biosynthesis of the indole alkaloid ajmaline.
References
- ↑ "Characterization of 2β(R)-17-O-acetylajmalan: acetylesterase--a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline". Zeitschrift für Naturforschung C 42 (4): 333–42. April 1987. PMID 2955586.
- ↑ "Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system". Planta 222 (5): 888–98. November 2005. doi:10.1007/s00425-005-0031-0. PMID 16133216.
External links
- Acetylajmaline+esterase at the US National Library of Medicine Medical Subject Headings (MeSH)
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