Biology:Adenosylcobinamide kinase

From HandWiki
Short description: Class of enzymes
adenosylcobinamide kinase
Identifiers
EC number2.7.1.156
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an adenosylcobinamide kinase (EC 2.7.1.156) is an enzyme that catalyzes the chemical reaction

RTP + adenosylcobinamide [math]\displaystyle{ \rightleftharpoons }[/math] adenosylcobinamide phosphate + RDP

Thus, the two substrates of this enzyme are RTP and adenosylcobinamide, whereas its two products are adenosylcobinamide phosphate and RDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is RTP:adenosylcobinamide phosphotransferase. Other names in common use include CobU, adenosylcobinamide kinase/adenosylcobinamide-phosphate, guanylyltransferase, and AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. This enzyme participates in porphyrin and chlorophyll metabolism.

References

  • "Purification and characterization of the bifunctional CobU enzyme of Salmonella typhimurium LT2. Evidence for a CobU-GMP intermediate". J. Biol. Chem. 270 (40): 23560–9. 1995. doi:10.1074/jbc.270.40.23560. PMID 7559521. 
  • "Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution". Biochemistry 37 (21): 7686–95. 1998. doi:10.1021/bi973178f. PMID 9601028. 
  • "Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site". Biochemistry 38 (40): 12995–3005. 1999. doi:10.1021/bi990910x. PMID 10529169. 
  • "Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation". J. Biol. Chem. 275 (36): 27576–86. 2000. doi:10.1074/jbc.M000977200. PMID 10869342. 
  • "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390–412. 2002. doi:10.1039/b108967f. PMID 12195810.