Biology:Carboxylesterase 3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene.[1][2][3][4]
Function
Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system.[4]
References
- ↑ "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase". FEBS Lett 458 (1): 17–22. Oct 1999. doi:10.1016/S0014-5793(99)01111-4. PMID 10518925.
- ↑ "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis". Clin Cancer Res 9 (13): 4983–91. Oct 2003. PMID 14581373.
- ↑ "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos 32 (5): 505–11. Apr 2004. doi:10.1124/dmd.32.5.505. PMID 15100172.
- ↑ 4.0 4.1 "Entrez Gene: CES3 carboxylesterase 3 (brain)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23491.
Further reading
- "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.". Blood 108 (9): 3103–11. 2006. doi:10.1182/blood-2006-03-011031. PMID 16840730.
- "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. 2004. doi:10.1002/pmic.200300770. PMID 15188402.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The sequence of the human genome.". Science 291 (5507): 1304–51. 2001. doi:10.1126/science.1058040. PMID 11181995. Bibcode: 2001Sci...291.1304V.
- "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver.". Biochim. Biophys. Acta 1174 (1): 72–4. 1993. doi:10.1016/0167-4781(93)90093-s. PMID 7916639. https://zenodo.org/record/1258379.
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