Biology:Choloyl-CoA hydrolase
From HandWiki
| Choloyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.27 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme choloyl-CoA hydrolase (EC 3.1.2.27) catalyzes the reaction
- choloyl-CoA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] cholate + CoA
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is choloyl-CoA hydrolase. Other names in common use include PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2.
References
- "Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism". J. Biol. Chem. 277 (2): 1128–38. 2002. doi:10.1074/jbc.M106458200. PMID 11673457.
- "Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver". Scand. J. Clin. Lab. Invest. 60 (2): 91–102. 2000. doi:10.1080/00365510050184903. PMID 10817395.
- Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
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