Biology:ERG11
From HandWiki
Sterol 14-demethylase | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | ERG11 | ||||||
Alt. symbols | CYP51F1 | ||||||
Entrez | 856398 | ||||||
HomoloGene | 55488 | ||||||
RefSeq (mRNA) | NM_001179137 | ||||||
RefSeq (Prot) | NP_011871 | ||||||
UniProt | P10614 | ||||||
Other data | |||||||
EC number | 1.14.14.154 | ||||||
Chromosome | VIII: 0.12 - 0.12 Mb | ||||||
|
ERG11 or Sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family CYP51, with the CYP Symbol CYP51F1.[1] ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into Ergosterol.[2]
References
- ↑ "Global analysis of protein expression in yeast". Nature 425 (6959): 737–41. October 2003. doi:10.1038/nature02046. PMID 14562106. Bibcode: 2003Natur.425..737G.
- ↑ "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research 46 (9): 1991–8. September 2005. doi:10.1194/jlr.M500153-JLR200. PMID 15995173.
Original source: https://en.wikipedia.org/wiki/ERG11.
Read more |