Biology:ERG11

From HandWiki
Sterol 14-demethylase
Identifiers
OrganismSaccharomyces cerevisiae
SymbolERG11
Alt. symbolsCYP51F1
Entrez856398
HomoloGene55488
RefSeq (mRNA)NM_001179137
RefSeq (Prot)NP_011871
UniProtP10614
Other data
EC number1.14.14.154
ChromosomeVIII: 0.12 - 0.12 Mb

ERG11 or Sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family CYP51, with the CYP Symbol CYP51F1.[1] ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into Ergosterol.[2]

References

  1. "Global analysis of protein expression in yeast". Nature 425 (6959): 737–41. October 2003. doi:10.1038/nature02046. PMID 14562106. Bibcode2003Natur.425..737G. 
  2. "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research 46 (9): 1991–8. September 2005. doi:10.1194/jlr.M500153-JLR200. PMID 15995173.