Biology:Fluoroacetyl-CoA thioesterase
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Fluoroacetyl-CoA thioesterase | |||||||||
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Identifiers | |||||||||
EC number | 3.1.2.29 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme fluoroacetyl-CoA thioesterase (EC 3.1.2.29; systematic name fluoroacetyl-CoA hydrolase) catalyses the following reaction:[1][2][3]
- fluoroacetyl-CoA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] fluoroacetate + CoA
Fluoroacetate is extremely toxic.
References
- ↑ "Fluoroacetyl-coenzyme-A hydrolase-like activity in Dichapetalum cymosum". J. Plant Physiol. 139: 369–372. 1992. doi:10.1016/s0176-1617(11)80352-4.
- ↑ "The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A". Chemistry & Biology 13 (5): 475–84. May 2006. doi:10.1016/j.chembiol.2006.02.014. PMID 16720268.
- ↑ "Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK". The Journal of Biological Chemistry 285 (29): 22495–504. July 2010. doi:10.1074/jbc.m110.107177. PMID 20430898.
External links
- Fluoroacetyl-CoA+thioesterase at the US National Library of Medicine Medical Subject Headings (MeSH)
![]() | Original source: https://en.wikipedia.org/wiki/Fluoroacetyl-CoA thioesterase.
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