Biology:GNAL
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.[1][2] Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.[3]
See also
- Second messenger system
- G protein-coupled receptor
- Heterotrimeric G protein
- Adenylyl cyclase
- Protein kinase A
- Olfactory receptors
References
- ↑ "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet 1 (2): 85–91. Jun 1993. doi:10.1038/ng0592-85. PMID 1302014. https://zenodo.org/record/1233383.
- ↑ "Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2774.
- ↑ Zhuang, Xiaoxi; Belluscio, Leonardo; Hen, Rene (15 August 2000). "GOLFα Mediates Dopamine D 1 Receptor Signaling". The Journal of Neuroscience 20 (16): RC91. doi:10.1523/JNEUROSCI.20-16-j0001.2000. PMID 10924528.
Further reading
- "Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.". Endocrinology 133 (6): 2508–14. 1994. doi:10.1210/endo.133.6.8243272. PMID 8243272.
- "Cellular and subcellular expression of Golf/Gs and Gq/G11 alpha-subunits in rat pancreatic endocrine cells.". J. Histochem. Cytochem. 47 (3): 289–302. 1999. doi:10.1177/002215549904700303. PMID 10026232.
- "Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia". Mol. Psychiatry 5 (5): 495–501. 2001. doi:10.1038/sj.mp.4000758. PMID 11032382.
- "Analysis of polymorphisms in the olfactory G-protein Golf in major depression". Psychiatr. Genet. 12 (1): 17–22. 2002. doi:10.1097/00041444-200203000-00002. PMID 11901355.
- "G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells". Oncogene 21 (25): 4020–31. 2002. doi:10.1038/sj.onc.1205498. PMID 12037684.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients". Psychiatr. Genet. 13 (2): 65–9. 2004. doi:10.1097/01.ypg.0000057881.80011.45. PMID 12782961.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Alternative transcripts and evidence of imprinting of GNAL on 18p11.2". Mol. Psychiatry 10 (11): 1017–25. 2005. doi:10.1038/sj.mp.4001713. PMID 16044173.
- "Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor". J. Recept. Signal Transduct. Res. 26 (4): 241–58. 2006. doi:10.1080/10799890600710592. PMID 16818375.
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