Biology:Glucosamine kinase
| Glucosamine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.8 | ||||||||
| CAS number | 9031-90-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Glucosamine kinase (EC 2.7.1.8) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The enzyme characterised from Schistosoma mansoni converts the hexose sugar, D-glucosamine (shown in its cyclic form) to D-glucosamine 6-phosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1] Two non-identical enzymes which catalyse the same reaction are known. One from Vibrio cholerae is involved in chitin breakdown.[2] The other, from Actinobacteria is part of biosynthetic pathways to compounds with applications as antibiotics.[3]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-glucosamine phosphotransferase. Other names in common use include glucosamine kinase (phosphorylating), ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase, and aminodeoxyglucose kinase.[4]
References
- ↑ Bueding, Ernest; MacKinnon, Joan A. (1955). "Hexokinases of Schistosoma mansoni". Journal of Biological Chemistry 215 (2): 495–506. doi:10.1016/S0021-9258(18)65971-X. PMID 13242546.
- ↑ Park, Jae Kweon; Wang, Lai-Xi; Roseman, Saul (2002). "Isolation of a Glucosamine-specific Kinase, a Unique Enzyme of Vibrio cholerae". Journal of Biological Chemistry 277 (18): 15573–15578. doi:10.1074/jbc.M107953200. PMID 11850417.
- ↑ Manso, José A.; Nunes-Costa, Daniela; Macedo-Ribeiro, Sandra; Empadinhas, Nuno; Pereira, Pedro José Barbosa (2019). "Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity". mBio 10 (3). doi:10.1128/mBio.00239-19. PMID 31088917.
- ↑ Enzyme 2.7.1.8 at KEGG Pathway Database.
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