Biology:Glycerate kinase
| Glycerate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.31 | ||||||||
| CAS number | 9026-61-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Glycerate kinase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Glyc_kinase | ||||||||||
| Pfam | PF02595 | ||||||||||
| InterPro | IPR004381 | ||||||||||
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Glycerate kinase (EC 2.7.1.31) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The enzyme characterised from liver and Escherichia coli converts D-glyceric acid to 3-phospho-D-glyceric acid by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2]
This enzyme is a transferases, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:(R)-glycerate 3-phosphotransferase. Other names in common use include glycerate kinase (phosphorylating), D-glycerate 3-kinase, D-glycerate kinase, glycerate-3-kinase, GK, D-glyceric acid kinase, and ATP:D-glycerate 2-phosphotransferase. This enzyme participates in 3 metabolic pathways: serine/glycine/threonine metabolism, glycerolipid metabolism, and glyoxylate-dicarboxylate metabolism.[3]
Some related enzymes produce the isomeric 2-phospho-D-glyceric acid.[4]
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1TO6, 1X3L, and 2B8N.
References
- ↑ "Studies on the purification and properties of D-glyceric acid kinase of liver". The Journal of Biological Chemistry 225 (2): 949–958. April 1957. doi:10.1016/S0021-9258(18)64892-6. PMID 13416296.
- ↑ "Purification and properties of D-glycerate 3-kinase from Escherichia coli". The Journal of Biological Chemistry 241 (3): 568–572. February 1966. doi:10.1016/S0021-9258(18)96874-2. PMID 5325263.
- ↑ Enzyme 2.7.1.31 at KEGG Pathway Database.
- ↑ "Only plant-type (GLYK) glycerate kinases produce d-glycerate 3-phosphate". FEBS Letters 582 (20): 3025–3028. September 2008. doi:10.1016/j.febslet.2008.07.038. PMID 18675808. Bibcode: 2008FEBSL.582.3025B.
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