Biology:Glycerol-1-phosphatase
| glycerol-1-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.21 | ||||||||
| CAS number | 37228-75-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme glycerol-1-phosphatase (EC 3.1.3.21) catalyzes the reaction
- glycerol 1-phosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] glycerol + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is glycerol-1-phosphate phosphohydrolase. Other names in common use include α-glycerophosphatase, α-glycerol phosphatase, glycerol 3-phosphatase, glycerol-3-phosphate phosphatase, and glycerol 3-phosphate phosphohydrolase. This enzyme participates in glycerolipid metabolism.
Among the organisms that have been shown to express this enzymatic activity are A. thaliana (plant) via the AtSgpp and AtGpp gene products;[1] D. salina (alga);[2] S. cerevisiae (fungus) via the GPP1/RHR2/YIL053W and GPP2/HOR2/YER062C gene products;[3][4] C. albicans (fungus) via the GPP1 gene product;[5] M. tuberculosis (bacteria) via the rv1692 gene product;[6] and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product.[7]
References
- ↑ "The kinetic analysis of the substrate specificity of motif 5 in a HAD hydrolase-type phosphosugar phosphatase of Arabidopsis thaliana". Planta 240 (3): 479–87. September 2014. doi:10.1007/s00425-014-2102-6. PMID 24915748.
- ↑ "Characterization and partial purification of DL-glycerol-1-phosphatase from Dunaliella salina". Biochimica et Biophysica Acta 661 (2): 199–204. 13 October 1981. doi:10.1016/0005-2744(81)90004-8. PMID 6252970.
- ↑ "Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae". Journal of Biological Chemistry 271 (23): 13875–81. 7 June 1996. doi:10.1074/jbc.271.23.13875. PMID 8662716.
- ↑ "The Yeast Glycerol 3-Phosphatases Gpp1p and Gpp2p Are Required for Glycerol Biosynthesis and Differentially Involved in the Cellular Responses to Osmotic, Anaerobic, and Oxidative Stress". Journal of Biological Chemistry 276 (5): 3555–63. 2 February 2001. doi:10.1074/jbc.M007164200. PMID 11058591.
- ↑ "Disruption of a gene encoding glycerol 3-phosphatase from Candida albicans impairs intracellular glycerol accumulation-mediated salt-tolerance". FEMS Microbiology Letters 245 (1): 107–16. April 2005. doi:10.1016/j.femsle.2005.02.031. PMID 15796987.
- ↑ "Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis". Proceedings of the National Academy of Sciences of the United States of America 110 (28): 11320–5. 25 June 2013. doi:10.1073/pnas.1221597110. PMID 23801751. Bibcode: 2013PNAS..11011320L.
- ↑ "Identification of a mammalian glycerol-3-phosphate phosphatase". Proceedings of the National Academy of Sciences of the United States of America 113 (4): E430–9. 11 January 2016. doi:10.1073/pnas.1514375113. PMID 26755581.
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