Biology:Glycoside hydrolase family 108
| Glycosyl hydrolase 108 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glyco_hydro_108 | ||||||||
| Pfam | PF05838 | ||||||||
| Pfam clan | CL0037 | ||||||||
| CAZy | GH108 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 108 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 108 CAZY GH_108 includes enzymes with lysozyme (N-acetylmuramidase) EC 3.2.1.17 activity. A glutamic acid residue within a conserved Glu-Gly-Gly-Tyr motif is essential for catalytic activity.[8] In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion.[9][10]
References
- ↑ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America 92 (15): 7090–4. July 1995. doi:10.1073/pnas.92.15.7090. PMID 7624375. Bibcode: 1995PNAS...92.7090H.
- ↑ "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–9. September 1995. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal 316 (Pt 2): 695–6. June 1996. doi:10.1042/bj3160695. PMID 8687420.
- ↑ "Home" (in en). http://www.cazy.org/.
- ↑ "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (Database issue): D490–5. January 2014. doi:10.1093/nar/gkt1178. PMID 24270786.
- ↑ "Glycoside Hydrolase Family 108" (in en). http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_108.
- ↑ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563. http://eprints.whiterose.ac.uk/122863/1/CAZypedia_20171003_Figures.pdf.
- ↑ "Coliphage N4 N-acetylmuramidase defines a new family of murein hydrolases.". J Mol Biol 366 (2): 406–19. 2007. doi:10.1016/j.jmb.2006.11.028. PMID 17174325.
- ↑ "COG3926 and COG5526: a tale of two new lysozyme-like protein families.". Protein Sci 14 (10): 2574–81. 2005. doi:10.1110/ps.051656805. PMID 16155206.
- ↑ "Cloning and characterization of a pair of genes that stimulate the production and secretion of Zymomonas mobilis extracellular levansucrase and invertase.". Biosci Biotechnol Biochem 58 (3): 526–30. 1994. doi:10.1271/bbb.58.526. PMID 7764692.
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