Biology:Holo-ACP synthase
| holo-citrate lyase synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.7.61 | ||||||||
| CAS number | 312492-44-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a holo-ACP synthase (EC 2.7.7.61) is an enzyme that catalyzes the chemical reaction
- 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase [math]\displaystyle{ \rightleftharpoons }[/math] holo-citrate lyase + diphosphate
Thus, the two substrates of this enzyme are 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA and apo-citrate lyase, whereas its two products are holo-citrate lyase and diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase. Other names in common use include 2'-(5"-phosphoribosyl)-3'-dephospho-CoA transferase, 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase, and CitX. This enzyme participates in two-component system - general.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2BDD.
References
- "Biosynthesis of the prosthetic group of citrate lyase". Biochemistry 39 (31): 9438–50. 2000. doi:10.1021/bi000401r. PMID 10924139. http://juser.fz-juelich.de/record/26938/files/19821.pdf.
- "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group". FEBS Lett. 483 (2–3): 165–8. 2000. doi:10.1016/S0014-5793(00)02105-0. PMID 11042274.
 |  |
