Biology:Inositol-1,4-bisphosphate 1-phosphatase
From HandWiki
| inositol-1,4-bisphosphate 1-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.57 | ||||||||
| CAS number | 111070-17-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction
- 1D-myo-inositol 1,4-bisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1D-myo-inositol 4-phosphate + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.
References
- "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. 1983. doi:10.1042/bj2120473. PMID 6309146.
- "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. 1987. PMID 3029066.
- "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+". J. Biol. Chem. 262 (33): 15946–52. 1987. PMID 2824473.
 |  |
