Biology:Lecithinase C

From HandWiki
Short description: Enzyme
Phospholipase C
Identifiers
EC number3.1.4.3
CAS number9001-86-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Phospholipase C (EC 3.1.4.3, lipophosphodiesterase I, Clostridium welchii α-toxin, Clostridium oedematiens β- and γ-toxins, lipophosphodiesterase C, phosphatidase C, heat-labile hemolysin, α-toxin) is an enzyme with systematic name phosphatidylcholine cholinephosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

a phosphatidylcholine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1,2-diacyl-sn-glycerol + phosphocholine

The bacterial enzyme is a zinc protein. It also acts on sphingomyelin and phosphatidylinositol.

References

  1. "[Lecithinase C in animal tissue]". Biokhimiia 17 (1): 77–81. 1952. PMID 13066482. 
  2. "The metal ion dependence of phospholipase C from Bacillus cereus". Biochimica et Biophysica Acta (BBA) - Enzymology 391 (2): 326–33. June 1975. doi:10.1016/0005-2744(75)90256-9. PMID 807246. 
  3. "Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma". The Journal of Biological Chemistry 261 (16): 7544–9. June 1986. PMID 3086312. 
  4. "Purification of Clostridium perfringens phospholipase C (alpha-toxin) by affinity chromatography on agarose-linked egg-yolk lipoprotein". Biochimica et Biophysica Acta (BBA) - Protein Structure 351 (1): 155–71. May 1974. doi:10.1016/0005-2795(74)90074-9. PMID 4365891. 

External links