Biology:N-sulfoglucosamine-3-sulfatase

From HandWiki
N-sulfoglucosamine-3-sulfatase
Identifiers
EC number3.1.6.15
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme N-sulfoglucosamine-3-sulfatase (EC 3.1.6.15}) catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.[1][2]

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic nameis N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradation of glycan structures.

References

  1. "Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate". Eur. J. Biochem. 148 (2): 359–65. 1985. doi:10.1111/j.1432-1033.1985.tb08847.x. PMID 3987694. 
  2. Leder IG (1980). "A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate". Biochem. Biophys. Res. Commun. 94 (4): 1183–9. doi:10.1016/0006-291X(80)90544-6. PMID 7396957.