Biology:Phosphatidylinositol-3,4-bisphosphate 4-phosphatase
From HandWiki
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.3.66 | ||||||||
| CAS number | 122653-78-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction
- 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase. Other names in common use include inositol-3,4-bisphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, phosphoinositide 4-phosphatase, inositol polyphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, and inositol polyphosphate 4-phosphatase type II. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
References
- "Evidence for at least four different inositol bisphosphatases in bovine brain". Eur. J. Biochem. 183 (1): 169–72. 1989. doi:10.1111/j.1432-1033.1989.tb14909.x. PMID 2546770.
- "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J. Biol. Chem. 270 (27): 16128–33. 1995. doi:10.1074/jbc.270.27.16128. PMID 7608176.
- "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J. Biol. Chem. 272 (38): 23859–64. 1997. doi:10.1074/jbc.272.38.23859. PMID 9295334.
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