Biology:Pimelyl-(acyl-carrier protein) methyl ester esterase

From HandWiki
Pimelyl-[acyl-carrier protein] methyl ester esterase
Identifiers
EC number3.1.1.85
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme Pimelyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85, BioH; systematic name pimelyl-[acyl-carrier protein] methyl ester hydrolase[1][2][3][4] catalyses the reaction

pimelyl-[acyl-carrier protein] methyl ester + H2O [math]\displaystyle{ \rightleftharpoons }[/math] pimelyl-[acyl-carrier protein] + methanol

This enzyme takes part in biotin biosynthesis in Gram-negative bacteria.

References

  1. "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". The Journal of Biological Chemistry 278 (28): 26039–45. July 2003. doi:10.1074/jbc.M303867200. PMID 12732651. 
  2. "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Molecular Microbiology 19 (3): 645–7. February 1996. doi:10.1046/j.1365-2958.1996.t01-4-442924.x. PMID 8830257. 
  3. "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Letters 513 (2-3): 299–304. February 2002. doi:10.1016/s0014-5793(02)02342-6. PMID 11904168. 
  4. "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nature Chemical Biology 6 (9): 682–8. September 2010. doi:10.1038/nchembio.420. PMID 20693992. 

External links