Biology:Polynucleotide 3'-phosphatase
From HandWiki
| polynucleotide 3′-phosphatase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.3.32 | ||||||||
| CAS number | 37288-16-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme polynucleotide 3′-phosphatase (EC 3.1.3.32) catalyzes the reaction
- a 3′-phosphopolynucleotide + H2O [math]\displaystyle{ \rightleftharpoons }[/math] a polynucleotide + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is polynucleotide 3'-phosphohydrolase. Other names in common use include 2′(3′)-polynucleotidase, DNA 3′-phosphatase, deoxyribonucleate 3′-phosphatase, and 5′-polynucleotidekinase 3′-phosphatase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1UJX and 2BRF.
References
- "The enzymatic cleavage of phosphate termini from polynucleotides". J. Biol. Chem. 242 (5): 936–50. 1967. PMID 4289819.
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