Biology:Protein phosphatase methylesterase-1
From HandWiki
| Protein phosphatase methylesterase-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.89 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme protein phosphatase methylesterase-1 (EC 3.1.1.89, PME-1, PPME1; systematic name (phosphatase 2A protein)-leucine ester acylhydrolase[1][2] catalyses the reaction
- [phosphatase 2A protein]-leucine methyl ester + H2O [math]\displaystyle{ \rightleftharpoons }[/math] [phosphatase 2A protein]-leucine + methanol
A key regulator of protein phosphatase 2A.
References
- ↑ "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". The Journal of Biological Chemistry 274 (20): 14382–91. May 1999. doi:10.1074/jbc.274.20.14382. PMID 10318862.
- ↑ "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell 133 (1): 154–63. April 2008. doi:10.1016/j.cell.2008.02.041. PMID 18394995.
External links
- Protein+phosphatase+methylesterase-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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