Biology:Ribonuclease Z
From HandWiki
TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme[1][2][3][4][5][6][7] that, among other things, catalyses the reactions involved in the maturation of tRNAs. Here, it endonucleolytically cleaves the RNA and removes extra 3' nucleotides from the tRNA precursor, generating the 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. Similarly, it processes tRNA-like molecules such as mascRNA.[8]
References
- ↑ "Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes". The EMBO Journal 21 (11): 2769–77. June 2002. doi:10.1093/emboj/21.11.2769. PMID 12032089.
- ↑ "tRNA 3' processing in plants: nuclear and mitochondrial activities differ". Biochemistry 39 (8): 2096–105. February 2000. doi:10.1021/bi992253e. PMID 10684660.
- ↑ "The plant tRNA 3' processing enzyme has a broad substrate spectrum". Biochemistry 40 (28): 8264–72. July 2001. doi:10.1021/bi0101953. PMID 11444972.
- ↑ "5' end maturation and RNA editing have to precede tRNA 3' processing in plant mitochondria". Proceedings of the National Academy of Sciences of the United States of America 95 (1): 108–13. January 1998. doi:10.1073/pnas.95.1.108. PMID 9419337.
- ↑ "The final cut. The importance of tRNA 3'-processing". EMBO Reports 2 (1): 17–20. January 2001. doi:10.1093/embo-reports/kve006. PMID 11252717.
- ↑ "A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima". The Journal of Biological Chemistry 279 (15): 15688–97. April 2004. doi:10.1074/jbc.M313951200. PMID 14749326.
- ↑ "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Research 31 (9): 2272–8. May 2003. doi:10.1093/nar/gkg337. PMID 12711671.
- ↑ "3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA". Cell 135 (5): 919–32. November 2008. doi:10.1016/j.cell.2008.10.012. PMID 19041754.
External links
- TRNase+Z at the US National Library of Medicine Medical Subject Headings (MeSH)
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