Biology:Sclareol cyclase

From HandWiki
Short description: Class of enzymes
Sclareol cyclase
Identifiers
EC number3.1.7.4
CAS number146838-18-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Sclareol cyclase (EC 3.1.7.4, geranylgeranyl pyrophosphate:sclareol cyclase, geranylgeranyl pyrophosphate-sclareol cyclase, GGPP:sclareol cyclase) is an enzyme with systematic name geranylgeranyl-diphosphate diphosphohydrolase (sclareol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 H2O [math]\displaystyle{ \rightleftharpoons }[/math] sclareol + diphosphate

This enzyme requires Mg2+ or Mn2+ for activity.

References

  1. "Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material". Phytochemistry 31 (10): 3391–3395. 1992. doi:10.1016/0031-9422(92)83692-R. 
  2. "Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice". Apoptosis 12 (4): 685–94. April 2007. doi:10.1007/s10495-006-0026-8. PMID 17260186. 
  3. "Biosynthesis of labdenediol and sclareol in cell-free extracts from trichomes of Nicotiana glutinosa". Planta 197 (4): 627–632. 1995. doi:10.1007/BF00191570. 

External links