Biology:Thymidylate 5'-phosphatase

From HandWiki
thymidylate 5′-phosphatase
Identifiers
EC number3.1.3.35
CAS number9026-80-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme thymidylate 5′-phosphatase (EC 3.1.3.35) catalyzes the reaction

thymidylate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] thymidine + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is thymidylate 5′-phosphohydrolase. Other names in common use include thymidylate 5′-nucleotidase, deoxythymidylate 5′-nucleotidase, thymidylate nucleotidase, deoxythymidylic 5′-nucleotidase, deoxythymidylate phosphohydrolase, and dTMPase.

References

  • "Deoxythymidylate 5′-nucleotidase. Purification and properties of an enzyme found after infection of Bacillus subtilis with phage SP5C". J. Biol. Chem. 241 (21): 5095–101. 1966. PMID 4958986.