Biology:UDP-N-acetylglucosamine kinase

From HandWiki
Short description: Class of enzymes
UDP-N-acetylglucosamine kinase
Identifiers
EC number2.7.1.176
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

UDP-N-acetylglucosamine kinase (EC 2.7.1.176, UNAG kinase, zeta toxin, toxin PezT, ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase) is an enzyme with systematic name ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase.[1][2] This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetyl-alpha-D-glucosamine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate

The phosphorylation of UDP-N-acetyl-D-glucosamine causes the inhibition of enzyme EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase.

These enzymes are found as part of plasmid-encoded[3] and chromosomal[4] bacterial toxin-antitoxin systems.

References

  1. "A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis". PLOS Biology 9 (3): e1001033. March 2011. doi:10.1371/journal.pbio.1001033. PMID 21445328. 
  2. "A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity". Molecular Microbiology 97 (3): 589–604. August 2015. doi:10.1111/mmi.13051. PMID 25943309. 
  3. "The toxin-antitoxin system of the streptococcal plasmid pSM19035". Journal of Bacteriology 187 (17): 6094–105. September 2005. doi:10.1128/JB.187.17.6094-6105.2005. PMID 16109951. 
  4. "Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae". The Journal of Biological Chemistry 282 (27): 19606–18. July 2007. doi:10.1074/jbc.m701703200. PMID 17488720. 

External links