1D-AL-LAD, also known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-AL-LAD, is a psychedelic drug of the lysergamide family related to AL-LAD.[1][2] It is thought to be a prodrug of AL-LAD similarly to how 1D-LSD is a prodrug of LSD.[1] 1D-AL-LAD was encountered online as a novel designer drug in 2023 and 2024.[1] It is said to have a dose of 100 to 300μg orally, a time to peak effects of 2 to 2.5hours, and a duration of 12hours.[1] The drug is said have "half the intensity" of LSD, with its effects including psychedelic visuals among others.[1] Although 1D-AL-LAD has reported to have been sold, some or all of the sold product appears to have actually been mislabeled 1T-AL-LAD.[2][3] 1D-AL-LAD is not an explicitly controlled substance in the United States[4] or in Canada.[5]
↑ 2.02.1"Synthesis and analytical characterization of 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD)". Drug Testing and Analysis17 (4): 494–501. April 2025. doi:10.1002/dta.3747. PMID38922764. "Since the end of 2023, a novel compound “1D-AL-LAD” appeared on X (formerly Twitter) and other websites. According to the Wikipedia article, “1D-LSD” is 1-(1,2-dimethylcyclobutanecarbonyl)-LSD (Figure 1c),22 a type of Group A LSD analog. However, there are no reports on this compound, except on Wikipedia. Meanwhile, our group identified 1T-LSD on the blotter paper labeled “1D-LSD”. 11 This was the first report of 1T-LSD and false labeling of 1D-LSD. Another group in Japan reported similar results for 1D-LSD and 1T-LSD.12 Additionally, 1,2-dimethylcyclobutanecarboxylic acid (a compound required to obtain 1D-LSD) is only dealt with by a few contract synthesis companies and is expensive. This implies that all or at least a certain percentage of “1D-AL-LAD” could be 1-(2-thienoyl) AL-LAD23 (1T-AL-LAD).".
↑"Identification of two lysergic acid diethylamide analogs, 1-(3-(trimethylsilyl) propionyl) lysergic acid diethylamide (1S-LSD) and 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD), in paper sheet products distributed on the internet". Forensic Toxicology43 (2): 370–376. July 2025. doi:10.1007/s11419-025-00718-3. PMID40180768. "Although the synthesized 1T-AL-LAD compound has been characterized previously [20], this is the first study to identify 1T-AL-LAD in the sheet product that was obtained on the internet. Product B was described as containing 1D-AL-LAD, a compound with a 1,2-dimethylcyclobutane- 1-carbonyl group at the N 1 position of LSD. However, as in the case of 1T-LSD (sold as 1D-LSD), it was a compound with a thiophene-2-carbonyl group at the N 1 position of AL- LAD, 1T-AL-LAD. It is necessary to confirm the structure by analysis, since the compound labeled on the product may actually be different one.".
