Chemistry:Antipsychotic ester

Short description: Class of prodrugs

Haloperidol decanoate, an antipsychotic ester.

An antipsychotic ester is an ester of an antipsychotic. They are used clinically as prodrugs to increase fat solubility and thereby prolong duration when antipsychotics are used as depot injectables.

List of clinically used antipsychotic esters

Typical antipsychotics

• Bromperidol decanoate
• Clopentixol decanoate
• Flupentixol decanoate
• Fluphenazine decanoate
• Fluphenazine enanthate
• Haloperidol decanoate
• Oxyprothepin decanoate
• Perphenazine decanoate
• Perphenazine enanthate
• Pipotiazine palmitate
• Pipotiazine undecylenate
• Zuclopentixol acetate
• Zuclopentixol decanoate

Atypical antipsychotics

• Aripiprazole lauroxil
• Paliperidone palmitate