Chemistry:Moperone
From HandWiki
Short description: Chemical compound
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| Trade names | Luvatren (discontinued) |
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| Formula | C22H26FNO2 |
| Molar mass | 355.453 g·mol−1 |
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Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class[1] which is marketed in Japan for the treatment of schizophrenia. It is an antagonist for the D2 (Ki 0.7–1.9 nM), D3 (Ki 0.1–1 nM), and 5-HT2A (Ki 52 nM) receptors. It also has a high binding affinity for the sigma receptors.[2][3]
References
- ↑ "The clinical position of moperone among the butyrophenones". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry 23 (1): 4–9. 1969. doi:10.3109/08039486909132154. PMID 5354545.
- ↑ "Moperone". Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. 2010. pp. 798. doi:10.1007/978-3-540-68706-1_1838. ISBN 978-3-540-68706-1. https://doi.org/10.1007/978-3-540-68706-1_1838. Retrieved 21 March 2022.
- ↑ "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. https://pdsp.unc.edu/databases/pdsp.php?receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testLigandDD=&testFreeRadio=testFreeRadio&testLigand=moperone&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query.
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