Chemistry:Mosapramine

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Short description: Antipsychotic medication
Mosapramine
Mosapramine.svg
Mosapramine-xtal-1993-ball-and-stick.png
Clinical data
Trade namesCremin (クレミン, Japan )
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral (tablets, oral solution)
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC28H35ClN4O
Molar mass479.07 g·mol−1
3D model (JSmol)
  (verify)

Mosapramine (Cremin) is an atypical antipsychotic used in Japan for the treatment of schizophrenia.[1][2] It is a potent dopamine antagonist with high affinity to the D2, D3, and D4 receptors,[3] and with moderate affinity for the 5-HT2 receptors.[4]

See also

References

  1. ↑ "Comparison of risperidone and mosapramine addition to neuroleptic treatment in chronic schizophrenia". Neuropsychobiology 39 (2): 81–5. 1999. doi:10.1159/000026565. PMID 10072664. 
  2. ↑ "Mosapramine" (in en). Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. 2010. pp. 76. doi:10.1007/978-3-540-68706-1_1839. ISBN 978-3-540-68706-1. https://doi.org/10.1007/978-3-540-68706-1_1839. Retrieved 21 March 2022. 
  3. ↑ "[The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 107 (5): 247–53. May 1996. doi:10.1254/fpj.107.247. PMID 8690306. 
  4. ↑ "Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy". Neuropsychopharmacology 12 (1): 57–64. February 1995. doi:10.1016/0893-133X(94)00064-7. PMID 7766287. 



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