Chemistry:Clopenthixol

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Short description: Antipsychotic medication
Clopenthixol
Clopenthixol structure.svg
Clinical data
Routes of
administration		Oral
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UNII
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Chemical and physical data
FormulaC22H25ClN2OS
Molar mass400.97 g·mol−1
3D model (JSmol)
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Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.[1]

Clopenthixol is a mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.[3]

Clopenthixol is not approved for use in the United States.


See also

References

  1. ↑ Drug discovery: a history. New York: Wiley. 2005. p. 410. ISBN 0-471-89980-1. https://books.google.com/books?id=Cb6BOkj9fK4C&pg=PA410. 
  2. ↑ Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. 2007. p. 516. ISBN 978-3-527-31058-6. https://books.google.com/books?id=yXD4QA-Y_Z0C&q=thioxanthene%201965%20pfizer&pg=PA516. [yes|permanent dead link|dead link}}]
  3. ↑ "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatrica Scandinavica 58 (5): 384–388. November 1978. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830. 

External links



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